1) It is possible to get the COVID-19 virus more than once. This rules out any form of herd immunity.from natural infection.

2) Vaccine immunity to COVID-19 wanes over time. This also makes herd immunity impossible.

3) The COVID-19 virus has a very fast mutation period. Every 2-4 months it seems to mutate to a different dominant variant. This short duration makes new vaccine development and new monoclonal antibody treatments hard to develop in time.

4) The COVID-19 virus has spread all over the globe. This makes international border closures unlikely to contain the virus.

5) Top Public Health universities say that COVID-19 may never go away.

6) COVID-19 has animal reservoirs in 29 other animal species so far. Some of the other infected animals include dogs, cats, panfolins, bats, lions, tigers, cougars, leopards, hyenas, deer, mink, monkeys, ferrets, otters, hippos, and a whole host of others.

7) The virus can impact all ages of people, which makes the expectation that kids get the virus and adults do not which many schools rely on impossible.

9) Getting 6 billion people on the planet to quarantine simultaneously is not a realistic expectation.

10) The virus keeps coming in waves, similar to a fractal or sinusoidal function

I think that with this combination, COVID-19 is going to be an ongoing diseases.